Features of gene polymorphism in comorbid patients with arterial hypertension and coronary heart disease

Abstract The problem of cardiovascular comorbidity becomes particularly relevant in the context a pandemic, since it is known that diseases (especially arterial hypertension – AH and coronary heart disease CHD) significantly increase frequency hospitalizations fatal outcomes patients with COVID-19. From these positions, fundamentally important to identify group individuals high prognostic probability developing combined pathology cohort hypertension. There hypothesis about genetic relationship between different diseases, which helps their common variants, turn makes possible determine new loci susceptibility for each comorbid conditions. Recent data indicate feasibility this from standpoint polymorphism. Material methods work based on results comprehensive examination 100 AH. A molecular study main variants gene polymorphism was performed DT 96 amplifier manufactured by DNA Technology (Russia). method determining polymerase chain reaction real-time detection results. Results All included were divided into 2 groups: without CHD 62% (62 people) 38% (38 people). relationships 9 genes involved pathogenesis isolated combination studied. When analyzing studied CHD, statistically significant differences obtained NOS3 T-786C polymorphic gene, more patients. Patients are characterized presence CC genotype C allele VOS3 (p=0.040 p=0.035), while TT marker characteristic It should be noted carrier “mutant” NO3S according our calculated statistical data, increases risk 5 times (OR=5.242, p=0.035). Conclusion aspects theoretically understanding mechanisms its formation. practical point view, valuable use modern approaches early prognostically unfavorable category developing. Funding Acknowledgement Type funding sources: None.